Epidural Administration of Liposome-Encapsulated Hydromorphone Provides Extended Analgesia in a Rodent Model of Stifle Arthritis

Liposome encapsulation of opioids by using an ammonium-sulfate–gradient loading technique significantly slows the release time of the drug. This study evaluated the duration of analgesia in a rodent model of monoarthritis after epidural administration of liposome-encapsulated hydromorphone (LE-hydro...

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Autori principali: Schmidt, Jennifer R, Krugner-Higby, Lisa, Heath, Timothy D, Sullivan, Ruth, Smith, Lesley J
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for Laboratory Animal Science 2011
Soggetti:
Anesthesia/Analgesia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148635/
https://ncbi.nlm.nih.gov/pubmed/21838980
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