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Cholesterol Secosterol Aldehydes Induce Amyloidogenesis and Dysfunction of Wild Type Tumor Protein p53

Epidemiologic and clinical evidence points to an increased risk of cancer when coupled with chronic inflammation. However, the molecular mechanisms that underpin this interrelationship remain largely unresolved. Herein we show that the inflammation-derived cholesterol 5,6-secosterol aldehydes, ather...

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Detalhes bibliográficos
Main Authors: Nieva, Jorge, Song, Byeong-Doo, Rogel, Joseph K., Kujawara, David, Altobel, Lawrence, Izharrudin, Alicia, Boldt, Grant E., Grover, Rajesh K., Wentworth, Anita D., Wentworth, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148486/
https://ncbi.nlm.nih.gov/pubmed/21802012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.02.018
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