Cholesterol Secosterol Aldehydes Induce Amyloidogenesis and Dysfunction of Wild Type Tumor Protein p53

Epidemiologic and clinical evidence points to an increased risk of cancer when coupled with chronic inflammation. However, the molecular mechanisms that underpin this interrelationship remain largely unresolved. Herein we show that the inflammation-derived cholesterol 5,6-secosterol aldehydes, ather...

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Autori principali: Nieva, Jorge, Song, Byeong-Doo, Rogel, Joseph K., Kujawara, David, Altobel, Lawrence, Izharrudin, Alicia, Boldt, Grant E., Grover, Rajesh K., Wentworth, Anita D., Wentworth, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148486/
https://ncbi.nlm.nih.gov/pubmed/21802012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.02.018
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