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Structural Basis for Sequence Specific DNA Binding and Protein Dimerization of HOXA13
The homeobox gene (HOXA13) codes for a transcription factor protein that binds to AT-rich DNA sequences and controls expression of genes during embryonic morphogenesis. Here we present the NMR structure of HOXA13 homeodomain (A13DBD) bound to an 11-mer DNA duplex. A13DBD forms a dimer that binds to...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3148250/ https://ncbi.nlm.nih.gov/pubmed/21829694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023069 |
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