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Nickel-Catalyzed Synthesis of Acrylamides from Alpha Olefins and Isocyanates

[Image: see text] The nickel(0)-catalyzed coupling of α-olefins and isocyanates proceeds in the presence of the N-heterocyclic carbene ligand IPr to provide α,β-unsaturated amides. Carbon-carbon bond formation occurs preferentially at the 2-position of the olefin. The N-tert-butyl amide products can...

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Autors principals: Schleicher, Kristin D., Jamison, Timothy F.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148187/
https://ncbi.nlm.nih.gov/pubmed/17269783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol063111x
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