Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML

In a zebrafish mutagenesis screen to identify genes essential for myelopoiesis, we identified an insertional allele hi1727, which disrupts the gene encoding RNA helicase dead-box 18 (Ddx18). Homozygous Ddx18 mutant embryos exhibit a profound loss of myeloid and erythroid cells along with cardiovascu...

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Hlavní autoři: Payne, Elspeth M., Bolli, Niccolò, Rhodes, Jennifer, Abdel-Wahab, Omar I., Levine, Ross, Hedvat, Cyrus V., Stone, Richard, Khanna-Gupta, Arati, Sun, Hong, Kanki, John P., Gazda, Hanna T., Beggs, Alan H., Cotter, Finbarr E., Look, A. Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2011
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148170/
https://ncbi.nlm.nih.gov/pubmed/21653321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-318022
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