L-leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway

Haploinsufficiency of ribosomal proteins (RPs) has been proposed to be the common basis for the anemia observed in Diamond-Blackfan anemia (DBA) and myelodysplastic syndrome with loss of chromosome 5q [del(5q) MDS]. We have modeled DBA and del(5q) MDS in zebrafish using antisense morpholinos to rps1...

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Autores principales: Payne, Elspeth M., Virgilio, Maria, Narla, Anupama, Sun, Hong, Levine, Michelle, Paw, Barry H., Berliner, Nancy, Look, A. Thomas, Ebert, Benjamin L., Khanna-Gupta, Arati
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2012
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447780/
https://ncbi.nlm.nih.gov/pubmed/22734070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-382986
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