G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase

Src activation involves the coordinated regulation of positive and negative tyrosine phosphorylation sites. The mechanism whereby receptor tyrosine kinases, cytokine receptors, and integrins activate Src is not known. Here, we demonstrate that granulocyte colony-stimulating factor (G-CSF) activates...

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Detalhes bibliográficos
Main Authors: Futami, Muneyoshi, Zhu, Quan-sheng, Whichard, Zakary L., Xia, Ling, Ke, Yuehai, Neel, Benjamin G., Feng, Gen-Sheng, Corey, Seth J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148159/
https://ncbi.nlm.nih.gov/pubmed/21636860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-261636
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