G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase

Src activation involves the coordinated regulation of positive and negative tyrosine phosphorylation sites. The mechanism whereby receptor tyrosine kinases, cytokine receptors, and integrins activate Src is not known. Here, we demonstrate that granulocyte colony-stimulating factor (G-CSF) activates...

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Bibliographic Details
Main Authors: Futami, Muneyoshi, Zhu, Quan-sheng, Whichard, Zakary L., Xia, Ling, Ke, Yuehai, Neel, Benjamin G., Feng, Gen-Sheng, Corey, Seth J.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Phagocytes, Granulocytes, and Myelopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148159/
https://ncbi.nlm.nih.gov/pubmed/21636860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-261636
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