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Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia

Chronic myeloid leukemia chronic phase (CML-CP) CD34(+) cells contain numerous DNA double-strand breaks whose unfaithful repair may contribute to chromosomal instability and disease progression to blast phase (CML-BP). These phenomena are often associated with the appearance of imatinib-resistant BC...

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Detalhes bibliográficos
Main Authors: Slupianek, Artur, Dasgupta, Yashodhara, Ren, Shu-yue, Gurdek, Ewa, Donlin, Milene, Nieborowska-Skorska, Margaret, Fleury, Fabrice, Skorski, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148158/
https://ncbi.nlm.nih.gov/pubmed/21653319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-307256
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