The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma

The RAS/RAF/MEK/ERK signaling pathway has been largely unexplored as a potential therapeutic target in lymphoma. The novel 2nd generation anti-MEK small molecule, AZD6244, down-regulated its direct downstream target, phospho-ERK (pERK) in germinal center and nongerminal center diffuse large B-cell l...

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Detalhes bibliográficos
Main Authors: Bhalla, Savita, Evens, Andrew M., Dai, Bojie, Prachand, Sheila, Gordon, Leo I., Gartenhaus, Ronald B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148157/
https://ncbi.nlm.nih.gov/pubmed/21628402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-340109
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