Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses

Collybistin (CB) is a guanine-nucleotide-exchange factor (GEF) selectively activating Cdc42. CB mutations cause X-linked mental retardation due to defective clustering of gephyrin, a postsynaptic protein associated with both glycine and GABA(A) receptors. Using a combination of biochemistry and cell...

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Bibliografiset tiedot
Päätekijät: Tyagarajan, Shiva K., Ghosh, Himanish, Harvey, Kirsten, Fritschy, Jean-Marc
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Company of Biologists 2011
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Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148131/
https://ncbi.nlm.nih.gov/pubmed/21807943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.086199
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