Expanded Potential for Recombinant Trisegmented Lymphocytic Choriomeningitis Viruses: Protein Production, Antibody Production, and In Vivo Assessment of Biological Function of Genes of Interest

The recombinant engineering of trisegmented lymphocytic choriomeningitis virus (LCMV) to express two genes of interest was recently reported. We used this technology to efficiently express green fluorescent protein (GFP) and the immunoregulatory gene product interleukin-10 (IL-10) in vitro, assess I...

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Bibliografiske detaljer
Main Authors: Popkin, Daniel L., Teijaro, John R., Lee, Andrew M., Lewicki, Hanna, Emonet, Sebastien, de la Torre, Juan Carlos, Oldstone, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147893/
https://ncbi.nlm.nih.gov/pubmed/21613399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00486-11
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