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c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4(+) T-Cell Differentiation and Allergic Lung Inflammation
The tyrosine kinase c-Abl is required for full activation of T cells, while its role in T-cell differentiation has not been characterized. We report that c-Abl deficiency skews CD4(+) T cells to type 2 helper T cell (Th2) differentiation, and c-Abl(−/−) mice are more susceptible to allergic lung inf...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3147793/ https://ncbi.nlm.nih.gov/pubmed/21690296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05383-11 |
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