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Effect of Ciprofloxacin Concentration on the Frequency and Nature of Resistant Mutants Selected from Pseudomonas aeruginosa mutS and mutT Hypermutators

The rapid emergence of drug resistance upon treatment of Pseudomonas aeruginosa infections with fluoroquinolones is a serious concern. In this study, we report the effect of hypermutability on the mutant selection window for ciprofloxacin (CIP) by comparing the hypermutator MPAO1 mutS and mutT strai...

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Main Authors: Morero, Natalia R., Monti, Mariela R., Argaraña, Carlos E.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147628/
https://ncbi.nlm.nih.gov/pubmed/21646492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01826-10
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