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Identifying Vulnerable Pathways in Mycobacterium tuberculosis by Using a Knockdown Approach
We constructed recombinant strains of Mycobacterium tuberculosis in which expression of specific genes was downregulated to identify vulnerable drug targets. Growth phenotypes in macrophages and culture were used to rank targets: the dprE1, clpP1, and fadD32 operons were the best targets and glnA1,...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3147394/ https://ncbi.nlm.nih.gov/pubmed/21642404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02880-10 |
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