p53 downregulates Down syndrome-associated DYRK1A through miR-1246

Several microRNAs mediate the functions of p53 family members. Here we characterize miR-1246 as a new target of this family. In response to DNA damage, p53 induces the expression of miR-1246 which, in turn, reduces the level of DYRK1A, a Down syndrome-associated protein kinase. Knockdown of p53 has...

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Bibliografiske detaljer
Main Authors: Zhang, Yu, Liao, Jun-Ming, Zeng, Shelya X, Lu, Hua
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147276/
https://ncbi.nlm.nih.gov/pubmed/21637297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.98
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