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p53 downregulates Down syndrome-associated DYRK1A through miR-1246
Several microRNAs mediate the functions of p53 family members. Here we characterize miR-1246 as a new target of this family. In response to DNA damage, p53 induces the expression of miR-1246 which, in turn, reduces the level of DYRK1A, a Down syndrome-associated protein kinase. Knockdown of p53 has...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3147276/ https://ncbi.nlm.nih.gov/pubmed/21637297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.98 |
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