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SIRT3 deacetylase: the Jekyll and Hyde sirtuin

Mitochondrial deacetylase SIRT3 protects against oxidative damage. In an article published online this month in EMBO reports, it is shown to also aggravate paracetamol-induced liver toxicity, calling for caution in trying to pharmacologically enhance SIRT3 activity.

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Bibliografski detalji
Glavni autori: Silberman, Dafne M, Mostoslavsky, Raul
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147273/
https://ncbi.nlm.nih.gov/pubmed/21738223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.147
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