The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity

Dysfunction of hepatic insulin receptor tyrosine kinase (IRTK) causes the development of type 2 diabetes. However, the molecular mechanism regulating IRTK activity in the liver remains poorly understood. Here, we show that phosphoinositide 3-kinase enhancer A (PIKE-A) is a new insulin-dependent enha...

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Bibliographic Details
Main Authors: Chan, Chi Bun, Liu, Xia, He, Kunyan, Qi, Qi, Jung, Dae Y, Kim, Jason K, Ye, Keqiang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
Subjects:
Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147257/
https://ncbi.nlm.nih.gov/pubmed/21720388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.108
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