Structural Coupling between RNA Polymerase Composition and DNA Supercoiling in Coordinating Transcription: a Global Role for the Omega Subunit?

In growing bacterial cells, the global reorganization of transcription is associated with alterations of RNA polymerase composition and the superhelical density of the DNA. However, the existence of any regulatory device coordinating these changes remains elusive. Here we show that in an exponential...

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Main Authors: Geertz, Marcel, Travers, Andrew, Mehandziska, Sanja, Sobetzko, Patrick, Chandra Janga, Sarath, Shimamoto, Nobuo, Muskhelishvili, Georgi
Format: Artigo
Jezik:Inglês
Izdano: American Society of Microbiology 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147163/
https://ncbi.nlm.nih.gov/pubmed/21810966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00034-11
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