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Effects of diadenosine tetraphosphate on FGF9-induced chloride flux changes in achondroplastic chondrocytes

Achondroplasia, the most common type of dwarfism, is characterized by a mutation in the fibroblast growth factor receptor 3 (FGFR3). Achondroplasia is an orphan pathology with no pharmacological treatment so far. However, the possibility of using the dinucleotide diadenosine tetraphosphate (Ap(4)A)...

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Autores principales: Huete, Fernando, Guzman-Aranguez, Ana, Ortín, Javier, Hoyle, Charles H. V., Pintor, Jesús
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Netherlands 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146644/
https://ncbi.nlm.nih.gov/pubmed/21559786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-011-9234-y
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