Targeting IL-12/IL-23 by Employing a p40 Peptide-Based Vaccine Ameliorates TNBS-Induced Acute and Chronic Murine Colitis

Interleukin (IL)-12 and IL-23 both share the p40 subunit and are key cytokines in the pathogenesis of Crohn’s disease. Previously, we have developed and identified three mouse p40 peptide-based and virus-like particle vaccines. Here, we evaluated the effects and immune mechanisms of the optimal vacc...

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Bibliographische Detailangaben
Hauptverfasser: Guan, Qingdong, Ma, Yanbing, Hillman, China-Li, Qing, Gefei, Ma, Allan G, Weiss, Carolyn R, Zhou, Gang, Bai, Aiping, Warrington, Richard J, Bernstein, Charles N, Peng, Zhikang
Format: Artigo
Sprache:Inglês
Veröffentlicht: ScholarOne 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146622/
https://ncbi.nlm.nih.gov/pubmed/21424108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2010.00252
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