Reversing Ongoing Chronic Intestinal Inflammation and Fibrosis by Sustained Block of IL-12 and IL-23 Using a Vaccine in Mice

Interleukin (IL)-12 and IL-23 that share subunit p40 are important cytokines in the pathogenesis of inflammatory bowel disease. We reported that mouse p40 peptide-based vaccines ameliorated intestinal inflammation in the prevention of trinitrobenzene sulfonic acid (TNBS)–induced murine colitis model...

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Vydáno v:Inflamm Bowel Dis
Hlavní autoři: Guan, Qingdong, Weiss, Carolyn R, Wang, Shuhe, Qing, Gefei, Yang, Xi, Warrington, Richard J, Bernstein, Charles N, Peng, Zhikang
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Original Basic Science Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205364/
https://ncbi.nlm.nih.gov/pubmed/29788053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ibd/izy142
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