Multi-Modal Strategies for Overcoming Tumor Drug Resistance: Hypoxia, Warburg’s Effect, Stem Cells, and Multifunctional Nanotechnology

Inefficiency in systemic drug delivery and tumor residence as well microenvironmental selection pressures contribute to the development of multidrug resistance (MDR) in cancer. Characteristics of MDR include abnormal vasculature, regions of hypoxia, up-regulation of ABC-transporters, aerobic glycoly...

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Hauptverfasser: Milane, Lara, Ganesh, Shanthi, Shah, Shruti, Duan, Zhen-feng, Amiji, Mansoor
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146561/
https://ncbi.nlm.nih.gov/pubmed/21497176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2011.03.032
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