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Modeling Disordered Regions in Proteins Using Rosetta
Protein structure prediction methods such as Rosetta search for the lowest energy conformation of the polypeptide chain. However, the experimentally observed native state is at a minimum of the free energy, rather than the energy. The neglect of the missing configurational entropy contribution to th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3146542/ https://ncbi.nlm.nih.gov/pubmed/21829444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022060 |
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