Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

Notch signaling is often and aberrantly activated by hypoxia during tumor progression; however, the exact pathological role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In this study, we aimed to define the mechanism of Notch ligand activation by hypoxia in bot...

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Hlavní autoři: Xing, Fei, Okuda, Hiroshi, Watabe, Misako, Kobayashi, Aya, Pai, Sudha K., Liu, Wen, Pandey, Puspa R., Fukuda, Koji, Hirota, Shigeru, Sugai, Tamotsu, Wakabayshi, Go, Koeda, Keisuke, Kashiwaba, Masahiro, Suzuki, Kazuyuki, Chiba, Toshimi, Endo, Masaki, Mo, Yin-Yuan, Watabe, Kounosuke
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145824/
https://ncbi.nlm.nih.gov/pubmed/21499308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.122
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