Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells

The molecular mechanisms that operate within the organ microenvironment to support metastatic progression remain unclear. Here we report that upregulation of the hyaluronan synthase HAS2 occurs in highly metastatic breast stem-like cancer cells (CSCs) defined by CD44+/CD24−/ESA+ phenotype, where it...

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Detalhes bibliográficos
Main Authors: Okuda, Hiroshi, Kobayashi, Aya, Xia, Bo, Watabe, Misako, Pai, Sudha K, Hirota, Shigeru, Xing, Fei, Liu, Wen, Pandey, Puspa R, Fukuda, Koji, Modur, Vishnu, Ghosh, Arnab, Wilber, Andrew, Watabe, Kounosuke
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404816/
https://ncbi.nlm.nih.gov/pubmed/22113945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1678
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