Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome characterized by benign tumors in multiple organs, including the brain and kidney. TSC-associated tumors exhibit hyperactivation of mammalian target of rapamycin complex 1 (mTORC1), a direct inhibitor of autophagy. Autophagy can either...

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Bibliographic Details
Main Authors: Parkhitko, Andrey, Myachina, Faina, Morrison, Tasha A., Hindi, Khadijah M., Auricchio, Neil, Karbowniczek, Magdalena, Wu, J. Julia, Finkel, Toren, Kwiatkowski, David J., Yu, Jane J., Henske, Elizabeth Petri
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145704/
https://ncbi.nlm.nih.gov/pubmed/21746920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104361108
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