The role of the C8 proton of ATP in the regulation of phosphoryl transfer within kinases and synthetases

BACKGROUND: The kinome comprises functionally diverse enzymes, with the current classification indicating very little about the extent of conserved regulatory mechanisms associated with phosphoryl transfer. The apparent K(m )of the kinases ranges from less than 0.4 μM to in excess of 1000 μM for ATP...

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Bibliographic Details
Main Authors: Kenyon, Colin P, Steyn, Anjo, Roth, Robyn L, Steenkamp, Paul A, Nkosi, Thokozani C, Oldfield, Lyndon C
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145573/
https://ncbi.nlm.nih.gov/pubmed/21749731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-12-36
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