Molecular Determinants of U-Type Inactivation in Kv2.1 Channels

Kv2.1 channels exhibit a U-shaped voltage-dependence of inactivation that is thought to represent preferential inactivation from preopen closed states. However, the molecular mechanisms underlying so-called U-type inactivation are unknown. We have performed a cysteine scan of the S3-S4 and S5-P-loop...

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Detalhes bibliográficos
Main Authors: Cheng, Y.M., Azer, J., Niven, C.M., Mafi, P., Allard, C.R., Qi, J., Thouta, S., Claydon, T.W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145267/
https://ncbi.nlm.nih.gov/pubmed/21806933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.06.025
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