N-type Inactivation Features of Kv4.2 Channel Gating

We examined whether the N-terminus of Kv4.2 A-type channels (4.2NT) possesses an autoinhibitory N-terminal peptide domain, which, similar to the one of Shaker, mediates inactivation of the open state. We found that chimeric Kv2.1(4.2NT) channels, where the cytoplasmic Kv2.1 N-terminus had been repla...

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Detalhes bibliográficos
Main Authors: Gebauer, Manuel, Isbrandt, Dirk, Sauter, Kathrin, Callsen, Britta, Nolting, Andreas, Pongs, Olaf, Bähring, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2004
Assuntos:
Channels, Receptors, and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303783/
https://ncbi.nlm.nih.gov/pubmed/14695263
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