JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia

The JAK2 V617F mutation is found in most patients with a myeloproliferative neoplasm and is sufficient to produce a myeloproliferative phenotype in murine retroviral transplantation or transgenic models. However, several lines of evidence suggest that disease phenotype is influenced by the level of...

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Bibliografiske detaljer
Main Authors: Li, Juan, Spensberger, Dominik, Ahn, Jong Sook, Anand, Shubha, Beer, Philip A., Ghevaert, Cedric, Chen, Edwin, Forrai, Ariel, Scott, Linda M., Ferreira, Rita, Campbell, Peter J., Watson, Steve P., Liu, Pentao, Erber, Wendy N., Huntly, Brian J. P., Ottersbach, Katrin, Green, Anthony R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145111/
https://ncbi.nlm.nih.gov/pubmed/20489053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-259747
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