The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial

BACKGROUND: Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary revascularisation in people without kidney disease, but its effects in people with moderate-to-severe kidney disease are uncertain. The SHARP trial aimed t...

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Autors principals: Baigent, Colin, Landray, Martin J, Reith, Christina, Emberson, Jonathan, Wheeler, David C, Tomson, Charles, Wanner, Christoph, Krane, Vera, Cass, Alan, Craig, Jonathan, Neal, Bruce, Jiang, Lixin, Hooi, Lai Seong, Levin, Adeera, Agodoa, Lawrence, Gaziano, Mike, Kasiske, Bertram, Walker, Robert, Massy, Ziad A, Feldt-Rasmussen, Bo, Krairittichai, Udom, Ophascharoensuk, Vuddidhej, Fellström, Bengt, Holdaas, Hallvard, Tesar, Vladimir, Wiecek, Andrzej, Grobbee, Diederick, de Zeeuw, Dick, Grönhagen-Riska, Carola, Dasgupta, Tanaji, Lewis, David, Herrington, William, Mafham, Marion, Majoni, William, Wallendszus, Karl, Grimm, Richard, Pedersen, Terje, Tobert, Jonathan, Armitage, Jane, Baxter, Alex, Bray, Christopher, Chen, Yiping, Chen, Zhengming, Hill, Michael, Knott, Carol, Parish, Sarah, Simpson, David, Sleight, Peter, Young, Alan, Collins, Rory
Format: Artigo
Idioma:Inglês
Publicat: Lancet Publishing Group 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145073/
https://ncbi.nlm.nih.gov/pubmed/21663949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(11)60739-3
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