Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis

BACKGROUND: Paracrine signaling between hepatic stellate cells (HSC) and liver endothelial cells (LEC) modulates fibrogenesis, angiogenesis, and portal hypertension. However, mechanisms regulating these processes are not fully defined. Sorafenib is a receptor tyrosine kinase inhibitor that blocks gr...

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Bibliografiska uppgifter
Huvudupphovsmän: Thabut, Dominique, Routray, Chittaranjan, Lomberk, Gwen, Shergill, Uday, Glaser, Kevin, Huebert, Robert, Patel, Leena, Masyuk, Tetyana, Blechacz, Boris, Vercnocke, Andrew, Ritman, Erik, Ehman, Richard, Urrutia, Raul, Shah, Vijay
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145033/
https://ncbi.nlm.nih.gov/pubmed/21567441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24427
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