Focal Adhesion Kinase Targeting Using In vivo Short Interfering RNA Delivery in Neutral Liposomes for Ovarian Carcinoma Therapy

PURPOSE: Focal adhesion kinase (FAK) plays a critical role in ovarian cancer cell survival and in various steps in the metastatic cascade. Based on encouraging in vitro results with FAK silencing, we examined the in vivo therapeutic potential of this approach using short interfering RNA (siRNA) in t...

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Main Authors: Halder, Jyotsnabaran, Kamat, Aparna A., Landen, Charles N., Han, Liz Y., Lutgendorf, Susan K., Lin, Yvonne G., Merritt, William M., Jennings, Nicholas B., Chavez-Reyes, Arturo, Coleman, Robert L., Gershenson, David M., Schmandt, Rosemarie, Cole, Steven W., Lopez-Berestein, Gabriel, Sood, Anil K.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144499/
https://ncbi.nlm.nih.gov/pubmed/16914580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-06-0021
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