Effect of Interleukin-8 Gene Silencing With Liposome-Encapsulated Small Interfering RNA on Ovarian Cancer Cell Growth

BACKGROUND: Interleukin-8 (IL-8) is a proangiogenic cytokine that is overexpressed in many human cancers. We investigated the clinical and biologic significance of IL-8 in ovarian carcinoma using human samples and orthotopic mouse models. METHODS: Tumor expression of IL-8 was assessed by immunohisto...

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Detalhes bibliográficos
Main Authors: Merritt, William M., Lin, Yvonne G., Spannuth, Whitney A., Fletcher, Mavis S., Kamat, Aparna A., Han, Liz Y., Landen, Charles N., Jennings, Nicholas, De Geest, Koen, Langley, Robert R., Villares, Gabriel, Sanguino, Angela, Lutgendorf, Susan K., Lopez-Berestein, Gabriel, Bar-Eli, Menashe M., Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770251/
https://ncbi.nlm.nih.gov/pubmed/18314475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djn024
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