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HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore
Centromeres of higher eukaryotes are epigenetically marked by the centromere-specific CENP-A nucleosome. New CENP-A recruitment requires the CENP-A histone chaperone HJURP. In this paper, we show that a LacI (Lac repressor) fusion of HJURP drove the stable recruitment of CENP-A to a LacO (Lac operon...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3144403/ https://ncbi.nlm.nih.gov/pubmed/21768289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201012017 |
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