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Limits to Catalysis by Ribonuclease A
Bovine pancreatic ribonuclease A (RNase A) catalyzes the cleavage of the P–O(5′) bond in RNA. Although this enzyme has been the object of much landmark work in bioorganic chemistry, the nature of its rate-limiting transition state and its catalytic rate enhancement had been unknown. Here, the value...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3144031/ https://ncbi.nlm.nih.gov/pubmed/21799547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1006/bioo.1995.1033 |
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