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Ribonuclease A: Revealing Structure–Function Relationships with Semisynthesis
Bovine pancreatic ribonuclease A (RNase A) catalyzes the cleavage of P–O(5′) bonds in RNA. Structural analyses had suggested that the active-site lysine residue (K41) may interact preferentially with the transition state for covalent bond cleavage, thus facilitating catalysis. Here, site-directed mu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137125/ https://ncbi.nlm.nih.gov/pubmed/21732653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja00136a001 |
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