Studies of the Mechanistic Details of the pH-dependent Association of Botulinum Neurotoxin with Membranes

Botulinum neurotoxin (BoNT) belongs to a large class of toxic proteins that act by enzymatically modifying cytosolic substrates within eukaryotic cells. The process by which a catalytic moiety is transferred across a membrane to enter the cytosol is not understood for any such toxin. BoNT is known t...

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Bibliographic Details
Main Authors: Mushrush, Darren J., Koteiche, Hanane A., Sammons, Morgan A., Link, Andrew J., Mchaourab, Hassane S., Lacy, D. Borden
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143659/
https://ncbi.nlm.nih.gov/pubmed/21652698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.256982
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