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Neuroprotection mediated by changes in the endothelial actin cytoskeleton

Cerebral blood flow is regulated by endothelium-derived nitric oxide (NO), and endothelial NO synthase–deficient (eNOS-deficient; eNOS(–/–)) mice develop larger cerebral infarctions following middle cerebral artery (MCA) occlusion. We report that disruption of Rho-mediated endothelial actin cytoskel...

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Publicado en:J Clin Invest
Autores principales: Laufs, Ulrich, Endres, Matthias, Stagliano, Nancy, Amin-Hanjani, Sepideh, Chui, Dao-Shan, Yang, Shui-Xiang, Simoncini, Tommaso, Yamada, Masaru, Rabkin, Elena, Allen, Philip G., Huang, Paul L., Böhm, Michael, Schoen, Frederick J., Moskowitz, Michael A., Liao, James K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2000
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Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314365/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10880044/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9639
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