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Silencing Suppressor of Cytokine Signaling-1 (SOCS1) in Macrophages Improves Mycobacterium tuberculosis Control in an Interferon-γ (IFN-γ)-dependent Manner
Protection against infection with Mycobacterium tuberculosis demands IFN-γ. SOCS1 has been shown to inhibit responses to IFN-γ and might thereby play a central role in the outcome of infection. We found that M. tuberculosis is a highly efficient stimulator of SOCS1 expression in murine and human mac...
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Main Authors: | , , , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
American Society for Biochemistry and Molecular Biology
2011
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3143647/ https://ncbi.nlm.nih.gov/pubmed/21622562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238287 |
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