A Hypomorphic Mutation in Lpin1 Induces Progressively Improving Neuropathy and Lipodystrophy in the Rat

The Lpin1 gene encodes the phosphatidate phosphatase (PAP1) enzyme Lipin 1, which plays a critical role in lipid metabolism. In this study we describe the identification and characterization of a rat model with a mutated Lpin1 gene (Lpin1(1Hubr)), generated by N-ethyl-N-nitrosourea mutagenesis. Lpin...

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Detalhes bibliográficos
Main Authors: Mul, Joram D., Nadra, Karim, Jagalur, Noorjahan B., Nijman, Isaac J., Toonen, Pim W., Médard, Jean-Jacques, Grès, Sandra, de Bruin, Alain, Han, Gil-Soo, Brouwers, Jos F., Carman, George M., Saulnier-Blache, Jean-Sébastien, Meijer, Dies, Chrast, Roman, Cuppen, Edwin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143639/
https://ncbi.nlm.nih.gov/pubmed/21715287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197947
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