Characterization of Sparstolonin B, a Chinese Herb-derived Compound, as a Selective Toll-like Receptor Antagonist with Potent Anti-inflammatory Properties

Blockade of excessive Toll-like receptor (TLR) signaling is a therapeutic approach being actively pursued for many inflammatory diseases. Here we report a Chinese herb-derived compound, sparstolonin B (SsnB), which selectively blocks TLR2- and TLR4-mediated inflammatory signaling. SsnB was isolated...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Liang, Qiaoli, Wu, Qinan, Jiang, Jihong, Duan, Jin'ao, Wang, Chao, Smith, Mark D., Lu, Hong, Wang, Qian, Nagarkatti, Prakash, Fan, Daping
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143611/
https://ncbi.nlm.nih.gov/pubmed/21665946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227934
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы