Characterization of Sparstolonin B, a Chinese Herb-derived Compound, as a Selective Toll-like Receptor Antagonist with Potent Anti-inflammatory Properties

Blockade of excessive Toll-like receptor (TLR) signaling is a therapeutic approach being actively pursued for many inflammatory diseases. Here we report a Chinese herb-derived compound, sparstolonin B (SsnB), which selectively blocks TLR2- and TLR4-mediated inflammatory signaling. SsnB was isolated...

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Detalhes bibliográficos
Main Authors: Liang, Qiaoli, Wu, Qinan, Jiang, Jihong, Duan, Jin'ao, Wang, Chao, Smith, Mark D., Lu, Hong, Wang, Qian, Nagarkatti, Prakash, Fan, Daping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143611/
https://ncbi.nlm.nih.gov/pubmed/21665946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227934
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