Lon Peptidase 1 (LONP1)-dependent Breakdown of Mitochondrial 5-Aminolevulinic Acid Synthase Protein by Heme in Human Liver Cells

5-Aminolevulinic acid synthase (ALAS-1) is the first rate controlling enzyme that controls cellular heme biosynthesis. Negative feedback regulation of ALAS-1 by the end product heme is well documented and provides the foundation for heme treatment of acute porphyrias, a group of diseases caused by g...

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Bibliographic Details
Main Authors: Tian, Qing, Li, Ting, Hou, Weihong, Zheng, Jianyu, Schrum, Laura W., Bonkovsky, Herbert L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143606/
https://ncbi.nlm.nih.gov/pubmed/21659532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.215772
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