Sulfated Glycosaminoglycans Are Required for Specific and Sensitive Fibroblast Growth Factor (FGF) 19 Signaling via FGF Receptor 4 and betaKlotho

Secreted from intestine, human fibroblast growth factor 19 (hFGF19) is an endocrine metabolic regulator that controls bile acid synthesis in the liver. Earlier studies have suggested that hFGF19 at 10–100 nm levels signals through FGF receptor 4 (FGFR4) in the presence of a co-receptor, betaKlotho,...

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Detalhes bibliográficos
Main Authors: Nakamura, Masao, Uehara, Yuriko, Asada, Masahiro, Honda, Emi, Nagai, Naoko, Kimata, Koji, Suzuki, Masashi, Imamura, Toru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143605/
https://ncbi.nlm.nih.gov/pubmed/21653700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.251140
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