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CTLA4Ig inhibits T cell–dependent B-cell maturation in murine systemic lupus erythematosus

Long-term administration of CTLA4Ig prevents the onset of disease in systemic lupus erythematosus–prone (SLE-prone) NZB/NZW F1 mice. To determine the mechanism of this effect, we engineered an adenovirus that expresses murine CTLA4Ig. Administration of a single high dose of this virus results in lon...

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Detalhes bibliográficos
Main Authors: Mihara, Masahiko, Tan, Irene, Chuzhin, Yelena, Reddy, Bhoompally, Budhai, Lalbachan, Holzer, Aton, Gu, Yun, Davidson, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC314360/
https://ncbi.nlm.nih.gov/pubmed/10880052
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