Immunoregulatory soluble CTLA-4 modifies effector T-cell responses in systemic lupus erythematosus

BACKGROUND: The inhibitory CTLA-4 molecule is a crucial regulator of immune responses and a target for therapeutic intervention in both autoimmunity and cancer. In particular, CTLA-4 is important in controlling antigen-specific immunity, including responses to autoantigens associated with autoimmune...

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Publicado en:Arthritis Res Ther
Autores principales: Dahal, Lekh N., Basu, Neil, Youssef, Hazem, Khanolkar, Rahul C., Barker, Robert N., Erwig, Lars P., Ward, Frank J.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973056/
https://ncbi.nlm.nih.gov/pubmed/27487771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1075-1
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