Loss of AS160 Akt Substrate Causes Glut4 Protein to Accumulate in Compartments That Are Primed for Fusion in Basal Adipocytes

The Akt substrate AS160 (TCB1D4) regulates Glut4 exocytosis; shRNA knockdown of AS160 increases surface Glut4 in basal adipocytes. AS160 knockdown is only partially insulin-mimetic; insulin further stimulates Glut4 translocation in these cells. Insulin regulates translocation as follows: 1) by relea...

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Bibliographische Detailangaben
Hauptverfasser: Brewer, Paul Duffield, Romenskaia, Irina, Kanow, Mark A., Mastick, Cynthia Corley
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143591/
https://ncbi.nlm.nih.gov/pubmed/21613213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.253880
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